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Animal studies have shown that multiple forms of carnitine, including L-carnitine, acetyl-L-carnitine, and propionyl-L-carnitine, can protect against cisplatin-induced kidney toxicity (Yurekli 2011

It is particularly effective in treating neurological disorders, neuropathies, and B12 deficiencies that cannot be corrected through oral supplementation

[3] Anti-Inflammatory and Gene-Regulatory Actions A 2012 bioinformatics analysis by Pickart et al., using the Broad Institute Connectivity Map, found GHK-Cu modulates expression of more than 4,000 human genes, with pathways spanning inflammation suppression, DNA repair, and antioxidant defense

In the meantime, cisplatin resistance was reversed by berberine and cisplatin combination therapy, which suppresses the PI3K/Akt signaling and increases caspase-3 and caspase-9 activation to cause apoptosis (116)