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Nature 486:410414 Clarke LE, Barres BA (2013) Emerging roles of astrocytes in neural circuit development

Both caspase-8 and caspase-9 participate in a cascade that culminates in the activation of caspase-3, which then cleaves several substrates, resulting in chromosomal DNA fragmentation and the cellular morphological changes characteristic of apoptosis

However, a noticeable effect on weight loss and fat burning will probably take several days to several weeks, depending on the metabolism, age, health, and lifestyle