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Inhibition of the first rate-limiting enzyme of one-carbon metabolism (PHGDH) has been shown to promote cell growth arrest, a phenomenon that occurs as a result of an accumulation of intracellular reactive oxygen species (ROS) following the inhibition of glutamine metabolism

Figure 2 2.3 DPI synergizes with vincristine and MitoQ in reducing cell viability of MNA NB cells Finding synergistic drug combinations allows for combining drugs at lower concentrations, which is an important strategy for enhancing therapeutic efficacy while minimizing adverse effects

At the conclusion of the 28-day treatment period, the efficacy of each treatment was assessed and mice were humanely euthanized using CO 2 gas

Nature 525 , 234238 (2015)

Chen YB, Li J, Quan Z, Li Y, Li Y, Tang