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Properties: Crystals from 50% ethanol, mp 195

269 These findings illustrate that PERK signaling exerts dose-, duration-, and context-dependent effects, complicating efforts to therapeutically manipulate this pathway

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As negative regulators of the mTORC1 pathway (Budanov and Karin, 2014), a positive regulator for nutrient-sensing of this pathway, under leucine deprivation