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Its the molecule that mitochondria use to convert nutrients into ATP, and its a direct substrate for sirtuins, the proteins that regulate DNA repair, gene expression, and the cellular stress response

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10.1016/j.cmet.2014.09.003 256 ShinD.LeeJ.YouJ

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Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene

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A.Da Silva, J.Dort, Z.Orfi, X.Pan, S.Huang, I.Kho, E.Heckel, G.Muscarnera, P.Piet van Vliet, L.Sturiale, A.Messina, D.Romeo, C.D.M.van Karnebeek, X.Wen, A.Hinek, T.Molina, G.Andelfinger, B.Ellezam, Y.Yamanaka, H.J.Olivos, C.R.Morales, J.Joyal, D.J.Lefeber, D.Garozzo, N.A.Dumont, A.V.Pshezhetsky N -acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function Science Advances 9(26), (2023) DOI: Abstract: Deleterious variants in N -acetylneuraminate pyruvate lyase (NPL) cause skeletal myopathy and cardiac edema in humans and zebrafish, but its physiological role remains unknown

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Cloning, functional analysis, and mitochondrial localization of Trypanosoma brucei monothiol glutaredoxin-1

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