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Other factors that may increase susceptibility to, or play a role in the development of, an upper respiratory infection in cats include: Age kittens and elderly cats are more susceptible Breed certain breeds like Persians and other flat-faced breeds appear to have a predisposition to develop upper respiratory infections Vaccination status unvaccinated cats are more susceptible Overall health cats with immune deficiencies are more susceptible Overcrowding, living in a multi-cat household, cattery, boarding facility or shelter Poor sanitation Contaminated crates, cages, bedding, bowls and clothing Stress How is respiratory tract infection in cats diagnosed