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Single-cell multi-omics approaches enable unprecedented resolution of metabolic heterogeneity, identifying distinct metabolic subpopulations and their vulnerabilities

Clin Cancer Res 2020, 26:10341044

The preservation of proteostasis plays a crucial role in cell survival and becomes even more important for nondividing cells such as neurons, whose proteostasis machineries are reduced with aging, causing an accumulation of damaged organelles and misfolded proteins (327329)

The problem is the gap between preclinical data and clinical evidence

1502 days), 99 patients died, and cumulative survival rates were 82.3% at 1 year, 59.5% at 3 years, and 41.6% at 5 years