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This could be partly due to increased oxidative stress under glucose-depleted conditions, since glycolysis also serves in anti-oxidative defense 32

Available from: Lassgue, B., Sorescu, D., Szcs, K., Yin, Q

10.1016/j.bioactmat.2024.07.031 100 WangY.ZhangC.ChengJ.YanT.HeQ.HuangD.et al (2024f)

Regardless, donor RGCs transplanted in the SR space must migrate through the host retina to arrive at the ganglion cell layer (GCL), which may decrease integration efficiency