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In order to improve the stability of 5-azacitidine and decitabine, a large number of second-generation cytidine analogs have been developed

Dormancy Period: Can remain a dormant fungus or years

Characterization of differentially methylated regions in 3 bovine imprinted genes: a model for studying human germ-cell and embryo development

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Larger stones, and stones that fail to pass or cause especially severe pain or obstruction and infection may require more aggressive therapies such as antibiotics, lithotripsy (therapy utilizing ultrasound shock waves to break stones into smaller fragments), or surgery to remove stones (Antonelli 2015)