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Mechanical stress is a significant component that induces ferroptosis in osteoarthritic chondrocytes

Here, we focused primarily on the acute mitochondrial impact of 5FU, and although we arrived at the combination of 5FU and mitochondrial inhibitors (more specifically, 5FU and metformin) somewhat serendipitously, we have now generated evidence to support the use of 5FU and metformin combinations not only in patients with resistant or relapsed disease as previously suggested by others, but also in treatment-naive, first-line chemotherapy settings

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Overall, Nrf2-targeted therapies remain at an experimental stage, necessitating further drug development for clinical use

Age-related decline in NAD+ can cause low energy and poor cognition