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Functional readouts of ovarian function and fertility were from 8 weeks (56 days) following chemotherapy, by comparison, the minimum period needed for primordial follicles to develop to the antral stage or ovulation in mice has been estimated from between 20 days (Pedersen, 1970), 42 days (Oakberg, 1979) to 47 days (Zheng et al, 2014), with a recent estimate of 1416 days for the primary follicle transition (Richard et al, 2023)

J Neurochem 116:858865

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Furthermore, the effect of pH was not considered during the simulations given the small dimensions of the calculated system

Enzymatic Regulation Studies: Laboratories examine how small molecules interact with metabolic enzymes and intracellular signaling mechanisms