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The answer is we still dont really know

Yang and colleagues monitored the changes in TJ protein expression and organization in vitro with human BMECs and in vivo with BALB/c mice post-SARS-CoV-2 infection ( Infected endothelial cells can also trigger a neuroinflammatory cascade within the brain by increasing mRNAs involved in processes such as inflammation, leukocyte migration, and angiogenesis ( Similarly, Cpn infection may also disrupt the BBB by damaging endothelial cells and altering the TJ arrangement, ultimately increasing permeability and promoting AD pathology ( in vitro increased adhesion molecule expression such as vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 ( in vitro increased the expression of surface ligands, lymphocyte function-associated antigen-1 and very late activation antigen-4, integrins that bind to intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, respectively

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Why can't you just add a random amount of water and call it a day

& Sassoe-Pognetto, M