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P21-Mediated Senescence Fate Programming and the Reversal Mechanism of DBD P21 (CDKN1A), a cell cycle inhibitory protein, serves as a central hub connecting the DNA damage response (DDR) with the senescence program

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This cell lineage has several functions regulating the physiology of metabolic-relevant tissues, such as the endothelium, liver and adipose tissues (196, 197)