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G.GrundmannM.HudsonB

There is no completed human efficacy trial

Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression

Although neem has been extensively investigated in the non-clinical setting, only a handful of clinical studies have been published, of which none were conducted in pregnant women (Pai et al., 2004)