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77 Increased excitatory neurotransmission, 78 enhanced non-auditory projections, 79 and changes in GABAergic transmission contribute to the excitatoryinhibitory imbalance

Currently, Setmelanotide is being tested as a therapeutic option for rare genetic disorders of obesity such as POMC deficiency, heterozygous deficiency obesity, and POMC epigenetic disorders (30-32)

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Another study found that patients with CAD, taking Bifidobacterium lactis, experienced significant improvements in angina, depression, and anxiety compared to those who received a placebo (34)

Management: Is managed by adjusting dietary intake, reducing environmental toxin exposure, and possibly using supplements to balance neurotransmitter levels