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39,71 This suggests the existence of an enzyme that decarboxylates DHNA to 1,4-naphthoquinone

The anti-apoptotic activity of TB-500 may involve the reduction of early cell death initiation signals and activation of the survival kinase Akt through complex formation with PINCH and integrin-linked kinase

Although oxidative stress, ultraviolet radiation and metabolic dysfunction are welldocumented etiological factors, growing evidence implicates epigenetic dysregulation as a critical pathogenic mechanism in ARCs

This makes them important targets in cancer therapy and gives them significant potential in inducing senescence [81]

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