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A direct result of the increase in RBC mass is an increase in the bloods ability to deliver oxygen directly to working muscles, so directly increasing aerobic capacity [150]

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This modification makes the molecule more stable in the digestive tract and allows it to cross the cell membrane more easily once it is in the blood

Although the study is limited by an amendment from a planned phase 3 trial with 630 patients to a phase 2 trial with 225 patients and different follow-up times between the groups, the data again support a benefit of iron chelation on the clinical outcome