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The underlying biology has shifted, the body has begun to defend its new lower set point, and the medication's effect has been overlaid by an adaptive response that the medication does not, on its own, fully overcome

10.1016/j.expneurol.2008.04.038 32 ChuK.-A.WangS.-Y.YehC.-C.FuT.-W.FuY.-Y.KoT.-L.et al (2019)

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"It's going to be quite the headache because we just know that we ain't going to be able to park in front of our house where we pay rent," said Georgia Jones

[11] -Glucuronidase contains several notable structural formations, including a type of -barrel known as a jelly roll barrel and a TIM barrel