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Similarly, the leucine sensor SESTRIN was shown to be necessary for the dietary-restriction-induced lifespan extension in Drosophila , while a constitutively active SESTRIN mutant, that cannot bind leucine, downregulates TORC1 activity and is sufficient to promote longevity even in fed flies (Lu J

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In particular, there is some evidence that eryptotic cells might undergo swelling, which is much less common [89]

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