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Inhibition of glutamate-cysteine ligase (GCL), an important enzyme in GSH biosynthesis, is the most widely used method to inhibit GSH biosynthesis

p53 is a tumor suppressor gene that is mainly involved in maintaining normal cell growth and inhibiting malignant proliferation, and participates in the process of DNA replication and repair (104)

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TL;DR Glutathione is a master antioxidant that naturally brightens skin by inhibiting melanin production and protecting against environmental damage It works through nine key mechanisms: reducing hyperpigmentation, evening skin tone, providing sun protection, enhancing radiance, minimising fine lines, improving texture, reducing inflammation, detoxifying cells, and supporting long-term skin health Visible changes typically appear after 2-4 weeks of consistent use, with optimal results achieved in 3-4 months Glutathione is generally safe but may cause mild gastrointestinal side effects in some users Professional guidance is recommended for determining optimal dosage and treatment duration based on individual skin needs Glutathione is often called the body's "master antioxidant" for good reason