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Standard cognitive protocol

Delays in diagnosis and subsequent initiation in treatment of pernicious anaemia have been shown to increase the risk of irreversible neurological damage involving both the central and peripheral nervous system, resulting in permanent symptoms, such as peripheral neuropathy, cognitive impairment and damage to the spinal cord (known as subacute combined degeneration of the spinal cord)[9,16]

Let's look at how that translates to dosing with a U-100 syringe: 5mg is in 100 units (1 mL) 1mg is in 20 units (0.2 mL) 0.5mg is in 10 units (0.1 mL) As you can see, a 1mg dose now requires twice the volume (20 units instead of 10)

This may be beginning to change

Studies examining fibroblast and endothelial cell systems show increased phosphorylation of focal adhesion kinase and paxillin, two proteins central to cytoskeletal organization and cell adhesion signaling