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This adds to the difficulty in reconciling MS under a single pathophysiological umbrella, but also has implications for therapeutic design: this cytodegenerative component is not expected to respond to current anti-inflammatory disease-modifying drugs targeting acute/adaptive peripheral autoimmunity

Radiat Res 100:115123 Weiss JF, Hoover RL, Kumar KS (1987) Selenium pretreatment enhances the radioprotective effect and reduces the lethal toxicity of WR-2721

Moderate deficiency causes peripheral neuropathy, characterized by numbness, tingling, and weakness in the hands and feet

All this to say, these are competitive results however the rates of diarrhea and vomiting could be a problem if they continue to develop the 6mg dose, and for Kailera, they need to conduct trials in the United States and elsewhere