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Notably, the mitochondrial uncoupling agent FCCP, which diminishes mitochondrial membrane potential and ATP production, did not influence cuproptosis, implying that ATP synthesis is dispensable for this process

Jan 2017;26(1):65-71

Guarnera G, DeRosa A, Camerini R

To compensate, the pancreas increases insulin production, but cannot achieve positive results, and a progressive disorder of lipid and glucose metabolism takes place