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doi:10.1159/000490284 Spiegel R, Kalla R, Mantokoudis G, et al

10.1007/s003359900830 19 CuiH.XieN.BanerjeeS.GeJ.GuoS.LiuG.et al (2019)

Limitations There are some limitations to this review that warrant discussion

For severe major depressive disorder [identified using a Patient Health Questionnaire (PHQ)-9 score 20], an integrated approach combining pharmacotherapy and psychotherapy is preferred