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However, changes in LGSH metabolism by Glo2 can also affect levels, and thus direct measurement of methylglyoxal could be helpful to further assess the production rate of this reactive metabolite

However, these emerging markers are still in the basic research stage, lacking large samples to validate their clinical sensitivity, specificity and predictive value, and the refinement of telomere length shortening measurement to the extent that it is substantially associated with the developmental potential of the embryo has yet to be thoroughly investigated

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