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This is why numbers are always interpreted in the context of your overall health, not in isolation

It is a co-factor for methionine synthase, an enzyme involved in the methylation cycle, which is crucial for the metabolism of amino acids and the production of neurotransmitters

When deficient, replacing it often restores appetite and energy and prevents longer-term harm

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When NNMT becomes overactive, particularly in adipose tissue, it depletes cellular NAD+ reserves while promoting fat storage and metabolic inefficiency