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We are finalizing that the lookback period for the median allowed amount, the 10th and 90th percentile allowed amounts, and count of allowed amounts is a time period of no less than 12 months and no longer than 15 months prior to posting the MRF

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Within each active month, the 5-days-on, 2-days-off schedule follows the same logic at the weekly level: it prevents tachyphylaxis (diminished response from constant exposure) while maintaining enough stimulus frequency to produce measurable visceral fat reduction

Semaglutide (Wegovy, approved June 2021) and tirzepatide (Zepbound, approved November 2023) represent the current standard of care for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity [7][8]

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