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An increasing number of studies have demonstrated the efficacy of secondary antioxidants, such as acetylcarnitine, to reduce or to block neuronal death that occurs in the pathophysiology of Alzheimer's disease

97 , 707713.e1 (2012)

[DOI] [PubMed] [Google Scholar] 68.Boles RG

Figure S2

In a mouse aging model induced by D-galactose, Polygonatum sibiricum Redout polysaccharide regulates the function of mitochondria-associated membranes (MAMs) by downregulating the expression of key proteins such as IP3R, GRP75, and VDAC1, as well as decreasing the expression of the mitochondrial calcium uniporter (MCU), maintaining intracellular calcium homeostasis (99)