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No.: HY-181928CAS No.: 3123529-62-1PARP1/c-Met-IN-3 (Compound L19) is a selective c-Met and PARP1 inhibitor, with an IC of 5.4 nM against 50 c-Met and an IC of 3.7 nM against 50 PARP1

10.1136/ard.2008.101279 23 MurrayC

VCAM-1 and ICAM-1 expression, induced by serum deprivation-mediated endothelial activation, was counteracted by PLC treatment (Fig 5H and 5I).The reduction of CAM expression by PLC was likely responsible for the inhibition of leukocyte adhesion, that characterizes endothelial activation (Fig 5J and 5K)

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