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JIA is a progressive rheumatic disease usually presenting in childhood, and its pathogenesis is characterized by chronic inflammation of the joints of unknown etiology

The FDA-approved vasopressin analogue, terlipressin (terli), improves renal function in pts with HRS-1 by reducing portal hypertension and increasing effective arterial volume and mean arterial pressure (MAP)a marker of the hemodynamic response to treatment

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For the research community this means that clinical doses and durations are not validated , most of todays research protocols rely on animal models and hypothetical extrapolations

10.1016/j.ejogrb.2014.10.041 159