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One representative agent is curcumin, a plant-based NF-B inhibitor, which has been confirmed in various tumor-bearing mouse models to exert antitumor effects with elevated tumor-suppressing effector immune cells, including CD8 + T cells, NK cells and M1 macrophages, and constrained immunosuppressive cells, including Tregs and MDSCs

A change in the steroid metabolic pathway in human testes showing deteriorated spermatogenesis

NSC proliferation in the SVZ was independent of seasons and was shown to be influenced by reduced melatonin secretion through pinealectomy in animal models of AD [152]