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Several studies found that high red meat consumption (a major TMAO source) increased colonic NF-B activity by 2.3-fold in UC patients compared to plant-based diets (107, 108)

doi: 10.3390/ph16101471 157

The overall risks for each of the two primary endpoints (the cardiovascular composite and the renal composite) were not reduced with darbepoetin alfa treatment (see Table 1), but the risk of stroke was increased nearly two-fold in the darbepoetin alfa -treated group versus the placebo group: annualized stroke rate 2.1% vs