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The use of such an ROS-responsive nanoplatform for drug formulation modification may provide a new strategy for not only the delivery of deucravacitinib but also other small-molecule drugs in the JAK family, which can offer a promising clinical translation strategy

This mechanism for ALT typically involves the transfer of an amino group from alanine to -ketoglutarate to yield glutamate and pyruvate

Yu X, Long YC (2016) Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis

Previous studies have reported that PKM2 is enzymatically active toward pyruvate only as a tetramer and acts as a transcription factor coactivator when tetrameric PKM2 dissociates into a dimer 28,29

Interestingly, when 5-amino-1MQ was applied to HEK-293 cells, another widely used cell line in research derived from human embryonic kidney cells, there was no significant impact on their growth