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doi: 10.3390/molecules2719661 58 RosenbaumCCOMathnaDPChavezMShieldsK

IGF-IR inhibitors resistance The high failure rate of anti-IGF-IR mAb/inhibitor monotherapy or combinational therapy in clinical trials promotes the investigators to inspect the mechanisms underlying resistance to IGF-IR inhibition in cancer and revisit the strategies to target IGF-IR pathway

However, IGF-1/IGF-1R has different effects on inflammation in different pain models

A., Carf Pavia, F., Rigogliuso, S., Giacomazza, D., Ghersi, G., & La Carrubba, V

Possible side effects may include mild pain or swelling at the injection site, headache, nausea, or anxiety