glutathione mitochondria Unearthing the secrets of mitochondrial ROS and in bioenergetics: Trends in Biochemical Sciences Mitochondrial glutathione: Features, regulation and

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Two isozymes of heme oxygenase play distinct role: HMOX1 , an inducible enzyme regulated by oxidative stress and transcription factors like NRF2 , and HMOX2 , a constitutively expressed form involved in normal cellular homeostasis [16]

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12 It is a chronic condition, persisting for at least three months and often for years or decades, that significantly impairs physical, emotional, and social functioning

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