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As one of the main active components of PM, rhein could up-regulate the mRNA and protein levels of Nrf2, HO-1, and glutamate-cysteine ligase catalytic subunit (GCLC), down-regulate the protein expression of NF-B, TNF- and caspase-3, increase the survival rate of LO2 cells, decreasing the apoptosis rate and acting as a hepatoprotective drug (Li et al., 2021b)

Practice parameters for the role of actigraphy in the study of sleep and circadian rhythms: an update for 2002

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Among patients for whom ECOG PS (n=1722) and smoking history (n=1516) were collected, 65% had an ECOG PS of 1, 36% had an ECOG PS of 0, and 84% were smokers

Improved outcome after peripheral nerve injury in mice with increased levels of endogenous -3 polyunsaturated fatty acids