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In particular, they frequently fail to account for age-associated changes, comorbidities, and human-specific pathological features (Vitek et al., 2020)

That logic backfires at low doses

Lowered glutathione levels have a direct relationship with free radical formation and an inverse relationship with autoimmune diseases involving the thyroid

Researchers have found women with a low selenium level are at a higher risk of thyroid disorders

For the purpose of looking for illness diagnostic indicators, liquid-phase mass spectrometry is used to systematically detect the alterations in small molecule metabolite patterns (39)