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The agency notes that the peptide is highly susceptible to protein aggregation and the accumulation of peptide-related manufacturing impurities when formulated for injection, which can trigger massive, systemic immune system reactions in human patients

What Physicians Can Do Engage constructively with the PCAC process

Important caveat: there are no completed controlled human clinical trials of injectable or systemic GHK-Cu

Certain groups may not get enough vitamin B12 or have trouble absorbing it: Many older adults, who do not have enough hydrochloric acid in their stomach to absorb the vitamin B12 naturally present in food

These persons may benefit from judicious phlebotomy