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Moreover, the mitochondrial abnormalities and elevated ROS levels have also been implicated in the pathogenesis of IIM (157159)

The lasso tool was used to outline the grey matter (GM) and white matter (WM) for each section and the threshold tool used to calculate the percentage of area stained in the GM and WM of each case

Furthermore, Clostridium scindens upregulates monoamine oxidase A (MAO-A) activity, promoting the oxidative deamination of serotonin into the inactive metabolite 5-hydroxyindoleacetic acid (5-HIAA) (Li et al., 2025)