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To examine the roles of NFAT5 and Akt1 affect NIK ubiquitination and degradation, cells were treated with NFAT5 or cIAP1/2 overexpression plasmids, SC79, or proteasome inhibitor MG132, respectively

Many patients are not diagnosed until significant thyroid dysfunction is detected through lab testing

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The absence of HER2 status in the database used for this study constitutes a significant limitation, as it restricts the direct classification of patients based on their HER2 expression, a critical prognostic and predictive biomarker in breast cancer

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