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While existing systematic reviews and meta-analyses are limited by narrow sampling frames focused on contemporary trials, this review adopts a distinct approach by exclusively for clinical trials and randomized controlled trials to strengthen the evidence base

However, the role of tannins, except for 7- O -galloyl-D-sedoheptulose, was not widely considered in the biological activity of C

2 g of leaves from each of the infiltrated tobacco plants were homogenized in 3 ml lysis buffer (50 mM Tris, pH7.5, 150 mM NaCl, 10 mM MgCl 2 , 1 % glycerol, 0.5 % Triton X-100, 1mM PMSF as protease inhibitor)