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In addition to PPAR-, SIRT1 also interacts with PGC-1, inducing the expression of mitochondrial genes involved in oxidative metabolism and fatty acid oxidation, while it also enhances leptin sensitivity by repressing PTP1B

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It is necessary to continue molecular research on the epithelial barrier in order to develop preventive guidelines for maintaining its tightness, to develop new methods for evaluation of its functionality and therapy in case of diagnosed damage