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Results IDD is marked by redox imbalance, ferroptosis activation, and inflammatory stress The NP tissue plays a pivotal role in maintaining the normal biomechanical function of IVDs, of which the cell loss and dysfunction directly contribute to the onset of IDD 7

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doi: 10.3390/ijms20143458 106

W., Xu, X

Therefore, as the master regulator of cellular defense mechanisms, the Nrf2-related pathway is essential for protecting against inflammatory tissue injury by upregulating antioxidant proteins and detoxifying enzymes [26]