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This is due to the fact that the supposed mutation that causes the disease is either extremely rare in occurrence (e.g., UCHL1 I93M) or present in control population at similar frequencies (e.g., Omi/HtrA2 G399S)

We also identified novel pathways implicated in sarcoidosis such as signaling by integrin-linked kinase, IL-8, and caveolar-mediated endocytic signaling in our studies comparing BAL cells from controls and sarcoidosis cases

Iqbal B, Ali J, Ganguli M, Mishra S, Baboota S

Butyrate acts as a histone deacetylase inhibitor, reversing aberrant histone deacetylation and restoring the expression of genes critical for tumor suppression

The programming parameters are balanced in the two groups (Supplementary Table 2)