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Los estudios in vitro emplean tpicamente concentraciones entre 1 nM y 10 M segn el endpoint celular

doi: 10.1523/JNEUROSCI.1749-20.2020 151 CuiYZhangZZhouXZhaoZZhaoRXuXet al

These findings have led to tofacitinib being considered as a potential therapeutic agent to address the impaired gut barrier characteristic of patients suffering from IBD

Glutamine, glycine, aspartate, 10-formyl THF, and CO 2 are used as substrates for the synthesis of inosine monophosphate (IMP)the intermediate product of AMP and GMP (Figure 1)