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Glucagon-like peptide-1 (GLP-1) receptor agonists represent a class of medications increasingly prescribed for type 2 diabetes management and, more recently, for chronic weight management

These include prodrug strategies, nanotechnology-based delivery systems, conjugation with different polymers (e.g., PEG), encapsulation with the use of metalorganic frameworks, targeted delivery using ligand conjugation (e.g., peptides and antibodies), or manufacture of inhalable devices (e.g., intranasal administration)

A pharmaceutical composition for use in preventing or treating oxidation damage to cells, comprising administering the pharmaceutical composition as described in any one of claims 5 to 11 to the cells

These findings suggest that elevated 4-HNE in diabetes mediates lipid peroxidationdriven myocardial injury and worsens cardiac dysfunction

68,69 Both MTHFD2 and MTHFD1 are markedly elevated and correlated with poor survival across human cancers