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Met is first metabolized by methionine adenosyltransferase (MAT) to form S-adenosylmethionine (SAMe, which is also abbreviated as AdoMet) (Figure 1)

Histone methylation usually compacts the DNA, restricting the access of transcription factors necessary for gene expression

& Nordberg, A

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Wnt5a activats Wnt/PCP pathway, upregulating Ras-related C3 botulinum toxin substrate 1(Rac), which can activate JNK, thus aggravating IR in adipose tissue