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A large number of patients lose a few percent of body weight over a period of months, enough in some cases to restore ovulation

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A local synthesis of estradiol by endometriotic tissue is suggested by the evidence of increased aromatase activity, associated with an overexpression of cyclooxygenase 2 (COX2) and increased prostaglandins

[7] The concentration of glutathione in the cytoplasm is significantly higher (ranging from 0.5-10 mM) compared to extracellular fluids (2-20 M), reaching levels up to 1000 times greater

doi: 10.1016/s0140-6736(89)91909-0