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Some examples include spontaneous conversions, replication errors, exposure to free radicals, etc

Accumulation of oxidized biomolecules associated with degeneration of DA neurons indicates the involvement of oxidative stress mechanisms [1], and the highly oxidizable aromatic structure of DA and its metabolites are thought to contribute to these processes [2]

The features listed by Hanifin & Rajka (1980) are those referred to most often in the literature

51 In each case, if metabolism fails to match the demands of the cell, cell function is impaired, or cell can undergo apoptosis

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