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A pH-responsive hyaluronic acid hydrogel for regulating the inflammation and remodeling of the ECM in diabetic wounds

These mechanisms may have either direct effect on organelles like mitochondria, endoplasmic reticulum, the cytoskeleton, microtubules and nucleus or indirect effect on cellular organelles through the activation and inhibition of signalling kinases, transcription factors and gene-expression profiles

Recent studies indicate that NRF2 regulates hundreds of genes related to redox homeostasis and other physiological processes, and that dysregulation of NRF2-regulated genes provides a logical explanation for direct and indirect connections between oxidant stress and more than 200 human diseases [20]

Pavlovic, T

doi: 10.1016/j.jprot.2017.10.004 31 EllervikCMandrup-PoulsenTNordestgaardBGLarsenLEAppleyardMFrandsenMet al